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interferes with synthesis of dermal components is twofold UVA irradiation increases the synthesis of a nonfunctional latent TGF- protein, and UVA wavelengths downregulate the expression of TbRII by broblasts within 8 hours of UV exposure99,102,103 The effect of UVA irradiation is a 90% reduction in skin broblast TbRII activation, which diminishes procollagen synthesis and directly contributes to the aged appearance of photodamaged skin102 TbRII mRNA expression is also diminished after UVA irradiation Total production reduced by 40% when compared to nonUVA exposed tissue Skin treated with TGF- 1 after UVA exposure results in a 20% increase in TbRII expression when compared to controls treated with UVA alone This suggests that topical TGF- 1 may act as a self-protecting inducer of the TbRII receptor, abrogating UVA-induced reduction in TbRII expression99 UVA irradiation reduces procollagen production by 75% The addition of TGF- 1 after UV irradiation blunts this reduction in collagen synthesis99 This data supports the speculation that quantitative reduction of collagen synthesis in photodamaged skin, accounted for by UV-induced changes in TGF/TbRII signaling, is a process that can be modi ed by the addition of TGF- 1 TGF- is a small growth factor protein with potent keratinocyte mitogenic activity TGF- binds to keratinocyte epidermal growth factor receptors (EGFRs) to stimulate keratinocyte proliferation TGFis produced by wounded keratinocytes that are exposed to human serum Fibrin contained within serum is the physiologic stimulus for keratinocyte synthesis of TGF- 104 TGFacts in an autocrine fashion to induce keratinocyte proliferation as well as keratinocyte expression of surface EGFR TGF- appears to be the strongest mitogen for keratinocytes, surpassing the activity of epidermal growth factor, keratinocyte growth factor, and TGF- 105 Epidermal growth factor receptor (EGFR) is a widely expressed cell surface transmembrane receptor with intrinsic protein-tyrosine kinase activity106,107 EGFR ligands include amphiregulin, betacellulin, epiregulin, heparin-binding EGF-like growth factor, and TGF- 108 Ligand binding to EGFR induces receptor dimerization and autophosphorylation, two steps necessary for EGFR activity106,107 The EGFR mediates cell-speci c anabolic or catabolic effects EGFR activation promotes keratinocyte proliferation106,108 and has been shown to be effective in reducing the healing time in partial-thickness skin wounds108 111 However, activated EGFR also acts as a negative growth factor stimulating the degradation of collagen and elastin through induction of ker-.

You might have noticed that in the previous Try This example, you had to set the $timeNow variable before starting the while loop and then again inside the loop every time through the loop With a dowhile loop, we don t have to set the $timeNow variable before starting the loop, because the loop s condition is checked at the end of the loop instead:

y = 2x + 3 and the SI version of the second equation is y = 2x + 4 The y-intercepts are 3 and 4, respectively That means the point (0, 3) lies on the line for the first equation, and the point (0, 4) lies on the line for the second equation

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When taken together as a two-by-two linear system, these equations have no common solution That means their graphs do not intersect, so we can t use their point of intersection as a graph-plotting aid But there s another way Both lines have slopes of 2 If we move n units to the right along either line (where n is any number), we must move 2n units downward to stay on the line Let s move to the right by 4 units along each line That means we must go downward by 8 units Starting at (0, 3), we ll end up at (4, 5) Starting at (0, 4), we ll end up at (4, 4)

<html> <head> <title> Using a PHP while Loop </title> </head> <body> <h1> Using a PHP while Loop </h1> < php $time = gettimeofday(); $start = $time[sec]; do { $time = gettimeofday(); $timeNow = $time[sec]; echo "I'm going to keep going for a tenth of a second!<br>"; } while ($timeNow < ($start + 01)) > </body> </html>

Connect the points Figure 17-7 shows the four points we ve found, and the two lines connecting them Note that the lines are parallel, so they have no intersection point These two lines, taken together, form the graph of the two-by-two linear system represented by the inconsistent equations

PHP also has a special loop to loop over all the members of data collections like arrays the foreach loop Here s what it looks like:

(4, 4) (4, 5)

as a two-by-two linear system where the independent variable is x and the dependent variable is y The lines are parallel and distinct On both axes, each increment represents 1 unit The SI forms of the equations are shown below the originals

The foreach loop is a handy one, because each time through the loop, it places the next element from the array into a variable that you can use inside the body of the loop Here s an example, foreachphp We start by creating an array of fruits:

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